Novel insecticides were recently introduced in public health by the World Health Organisation (WHO) to counter pyrethroid resistance threats in African malaria vectors. To prolong their effectiveness, potential cross-resistance from promiscuous pyrethroid metabolic resistance mechanisms must be elucidated.
In our new paper in Cell Reports, Tchouakui et al used recently detected P450 DNA-based markers of pyrethroid resistance in Anopheles funestus, coupled with extensive in-vivo and in-vitro function validation to demonstrate that some P450 genes used by mosquitoes in Africa to survive insecticide-treated nets, are now making them more vulnerable to Chlorfenapyr, used on novel nets. This now allows to better guide control programmes.
Read more: https://doi.org/10.1016/j.celrep.2024.114566